The beauty of bacteriophage T4 research: Lindsay W. Black and the T4 head assembly

dc.contributor.authorKuhn, Andreas
dc.contributor.authorThomas, Julie A.
dc.date.accessioned2024-10-23T12:25:51Z
dc.date.available2024-10-23T12:25:51Z
dc.date.issued2022de
dc.description.abstractViruses are biochemically complex structures and mainly consist of folded proteins that contain nucleic acids. Bacteriophage T4 is one of most prominent examples, having a tail structure that contracts during the infection process. Intracellular phage multiplication leads to separate self-directed assembly reactions of proheads, tails and tail fibers. The proheads are packaged with concatemeric DNA produced by tandem replication reactions of the parental DNA molecule. Once DNA packaging is completed, the head is joined with the tail and six long fibers are attached. The mature particles are then released from the cell via lysis, another tightly regulated process. These processes have been studied in molecular detail leading to a fascinating view of the protein-folding dynamics that direct the structural interplay of assembled complexes. Lindsay W. Black dedicated his career to identifying and defining the molecular events required to form the T4 virion. He leaves us with rich insights into the astonishingly precise molecular clockwork that co-ordinates all of the players in T4 assembly, both viral and cellular. Here, we summarize Lindsay’s key research contributions that are certain to stimulate our future science for many years to come.en
dc.identifier.urihttps://hohpublica.uni-hohenheim.de/handle/123456789/16813
dc.identifier.urihttps://doi.org/10.3390/v14040700
dc.language.isoengde
dc.rights.licensecc_byde
dc.source1999-4915de
dc.sourceViruses; Vol. 14, No. 4 (2022) 700de
dc.subjectT4 bacteriophage
dc.subjectHead assembly
dc.subjectDNA packaging
dc.subjectInternal proteins
dc.subjectGiant phage
dc.subject.ddc630
dc.titleThe beauty of bacteriophage T4 research: Lindsay W. Black and the T4 head assemblyen
dc.type.diniArticle
dcterms.bibliographicCitationViruses, 14 (2022), 4, 700. https://doi.org/10.3390/v14040700. ISSN: 1999-4915
dcterms.bibliographicCitation.issn1999-4915
dcterms.bibliographicCitation.issue4
dcterms.bibliographicCitation.journaltitleViruses
dcterms.bibliographicCitation.volume14
local.export.bibtex@article{Kuhn2022, url = {https://hohpublica.uni-hohenheim.de/handle/123456789/16813}, doi = {10.3390/v14040700}, author = {Kuhn, Andreas and Thomas, Julie A.}, title = {The Beauty of Bacteriophage T4 Research: Lindsay W. Black and the T4 Head Assembly}, journal = {Viruses}, year = {2022}, volume = {14}, number = {4}, }
local.export.bibtexAuthorKuhn, Andreas and Thomas, Julie A.
local.export.bibtexKeyKuhn2022
local.export.bibtexType@article
local.title.fullThe beauty of bacteriophage T4 research: Lindsay W. Black and the T4 head assembly

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