Browsing by Person "Kluttig, Alexander"

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    Association between vitamin D status and eryptosis - results from the German National Cohort Study
    (2023) Ewendt, Franz; Schmitt, Marvin; Kluttig, Alexander; Kühn, Julia; Hirche, Frank; Kraus, Frank B.; Ludwig-Kraus, Beatrice; Mikolajczyk, Rafael; Wätjen, Wim; Bürkner, Paul-Christian; Föller, Michael; Stangl, Gabriele I.; Ewendt, Franz; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany; Schmitt, Marvin; Cluster of Excellence SimTech, University of Stuttgart, Stuttgart, Germany; Kluttig, Alexander; Institute of Medical Epidemiology, Biostatistics, and Informatics, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), Germany; Kühn, Julia; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany; Hirche, Frank; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany; Kraus, Frank B.; Central Laboratory, Department of Laboratory Medicine, University Hospital Halle, Halle (Saale), Germany; Ludwig-Kraus, Beatrice; Central Laboratory, Department of Laboratory Medicine, University Hospital Halle, Halle (Saale), Germany; Mikolajczyk, Rafael; Institute of Medical Epidemiology, Biostatistics, and Informatics, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), Germany; Wätjen, Wim; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany; Bürkner, Paul-Christian; Cluster of Excellence SimTech, University of Stuttgart, Stuttgart, Germany; Föller, Michael; Department of Physiology, University of Hohenheim, Stuttgart, Germany; Stangl, Gabriele I.; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
    Vitamin D, besides its classical effect on mineral homeostasis and bone remodeling, can also modulate apoptosis. A special form of apoptosis termed eryptosis appears in erythrocytes. Eryptosis is characterized by cell shrinkage, membrane blebbing, and cell membrane phospholipid disorganization and associated with diseases such as sepsis, malaria or iron deficiency, and impaired microcirculation. To our knowledge, this is the first study that linked vitamin D with eryptosis in humans. This exploratory cross-sectional trial investigated the association between the vitamin D status assessed by the concentration of plasma 25-hydroxyvitamin D (25(OH)D) and eryptosis. Plasma 25(OH)D was analyzed by LC–MS/MS, and eryptosis was estimated from annexin V-FITC-binding erythrocytes by FACS analysis in 2074 blood samples from participants of the German National Cohort Study. We observed a weak but clear correlation between low vitamin D status and increased eryptosis ( r  =  − 0.15; 95% CI [− 0.19, − 0.10]). There were no differences in plasma concentrations of 25(OH)D and eryptosis between male and female subjects. This finding raises questions of the importance of vitamin D status for eryptosis in terms of increased risk for anemia or cardiovascular events.